“細(xì)胞周期調(diào)控因子34抗體,Anti-CDC34/UBC3抗體”應(yīng)用于IHC、WB、 IF、IP、ELISA,質(zhì)量保證,無(wú)效免費(fèi)退換,另外本公司生產(chǎn)經(jīng)營(yíng)各種標(biāo)記二抗、免疫印跡常用試劑、免疫組化常用試劑,咨詢!
產(chǎn)品介紹:
【產(chǎn)品名稱】:細(xì)胞周期調(diào)控因子34抗體,Anti-CDC34/UBC3抗體
【產(chǎn)品類型】:一抗
【產(chǎn)品編號(hào)】:BYk-1392R
【相關(guān)標(biāo)記】: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
【性 狀】: Lyophilized or Liquid
【濃 度】: 1mg/1ml
【亞 型】: IgG
【規(guī) 格】:0.1ml/100ug,0.2ml/200ug
【抗體來(lái)源】: Rabbit OR MOUSE
【克隆類型】: polyclonal or monoclonal
【產(chǎn)品用途】:科研實(shí)驗(yàn),用于免疫組化實(shí)驗(yàn),WB實(shí)驗(yàn)、IF、IP、ELISA實(shí)驗(yàn),相應(yīng)的標(biāo)記抗體有HRP標(biāo)記抗體,F(xiàn)ITC標(biāo)記,BIO等。
【貯 存】: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
【詳細(xì)介紹】: The Cdc 34 gene represents a mammalian homolog of the group of yeast Cdc 34 genes required for the late G1 - S phase transition. A key negative regulator of mitosis, the protein kinase Wee 1, is degraded in a Cdc 34 dependent fashion in Xenopus egg extracts. This proteolysis event is required for a timely entrance into mitosis and is inhibited when DNA replication is blocked. Therefore, the DNA replication checkpoint can prevent mitosis by suppressing the proteolysis of Wee 1 during S phase. The human Cdc 34 gene is located on the far omeric region of 19p13. Mutants in the gene Cdc 34 of the yeast Saccharomyces cerevisiae are defective in the transition from G1 to the S phase of the cell cycle. This gene was cloned and shown to encode a 295 residue protein that has substantial sequence similarity to yeast Rad6 protein required for a variety of cellular functions including DNA repair and was recently shown to encode a ubiquitin conjugating enzyme. When produced in Escherichia coli, the Cdc 34 gene product catalyzes the covalent attachment of ubiquitin to histones H2A and H2B in vitro, demonstrating that the Cdc 34 protein is another distinct member of the family of ubiquitin conjugating enzymes. The cell cycle function of Cdc 34 is thus likely to be mediated by the ubiquitin conjugating activity of its product.
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