“半胱胺酸蛋白酶蛋白-12抗體，Anti-Caspase-12抗體”應(yīng)用于IHC、WB、 IF、IP、ELISA，質(zhì)量保證，無效免費(fèi)退換，另外本公司生產(chǎn)經(jīng)營各種標(biāo)記二抗、免疫印跡常用試劑、免疫組化常用試劑，咨詢！
產(chǎn)品介紹：
【產(chǎn)品名稱】：半胱胺酸蛋白酶蛋白-12抗體，Anti-Caspase-12抗體
【產(chǎn)品類型】：一抗
【產(chǎn)品編號(hào)】：BYk-1105R
【相關(guān)標(biāo)記】: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
【性 狀】： Lyophilized or Liquid
【濃 度】： 1mg/1ml
【亞 型】： IgG
【規(guī) 格】：0.1ml/100ug，0.2ml/200ug
【抗體來源】： Rabbit OR MOUSE
【克隆類型】： polyclonal or monoclonal
【產(chǎn)品用途】：科研實(shí)驗(yàn)，用于免疫組化實(shí)驗(yàn)，WB實(shí)驗(yàn)、IF、IP、ELISA實(shí)驗(yàn)，相應(yīng)的標(biāo)記抗體有HRP標(biāo)記抗體，F(xiàn)ITC標(biāo)記，BIO等。
【貯 存】： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
【詳細(xì)介紹】：Three distinct signaling pathways lead to apoptosis. The death receptor and mitochondrion pathways are the two mains, which involve respectively caspase-8 and caspase-9. The endoplasmic reticulum stress is the third apoptotic pathway and involves caspase-12. Localized to the ER but not to cytoplasm or mitochondria, caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including g-secretase presenilin and b-amyloid precursor protein （APP）. Caspase-12 mediates ER stress-induced apoptosis as well as cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues.
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