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Alzet滲透泵工作原理

時間:2023/9/28閱讀:910
分享:

Alzet滲透泵(ALZET Osmotic Pump),又名為Alzet植入式膠囊滲透壓泵,是一種高效動物給藥系統(tǒng)。Alzet滲透泵體積小巧,常用于大鼠、小鼠及其他實驗動物的藥劑泵送。Alzet滲透泵共有12個型號的產(chǎn)品,可根據(jù)給藥時間、給藥速度來選擇合適的型號,具體的產(chǎn)品型、泵容積、泵送速率見下表:

Alzet滲透泵可植入動物的皮下或者腹腔內(nèi),亦可連接上導(dǎo)管,輸送到動脈或者靜脈內(nèi),從而到達(dá)局部組織或者器官,從歷年的文獻(xiàn)來看,科學(xué)家們已經(jīng)將Alzet滲透泵應(yīng)用到了如腦、脊髓、肝臟、脾臟等器官或組織,更多應(yīng)用,靜待科學(xué)家們的開發(fā),讓我們拭目以待吧。

由于Alzet滲透泵釋放原理,使得很多化學(xué)試劑、藥劑或者其他物質(zhì),通過Alzet滲透泵應(yīng)用到科研試驗中。那讓我們一起來了解一下Alzet滲透泵的原理和運行機(jī)制吧。

Alzet滲透泵分為三層,分別是最外層的半透膜材料,中間層的高滲鹽夾層,最內(nèi)層的貯藥囊,還有一根導(dǎo)流管和貯藥囊。由于膠囊與所植入部位的組織或器官之間的滲透壓的差異度產(chǎn)生的驅(qū)動,驅(qū)使藥物通過導(dǎo)流管進(jìn)入貯藥囊內(nèi)。泵本身是一個富含高鹽濃度的膠囊,是屬于高滲透度的環(huán)境,會吸進(jìn)膠囊外的體液。體液經(jīng)過膠囊最外層的半透膜(semipermeable membrane),被高滲透壓的高鹽吸進(jìn)來,會壓擠可壓縮的儲液槽(reservoir)。儲液槽一經(jīng)向內(nèi)壓縮,同時即會把儲液槽中的藥劑溶液,以已知、可控制的速率推擠出膠囊。由于被擠壓后的儲液槽是無法恢復(fù)原狀、無法重新灌注藥劑,所以此膠囊泵是只能用一次的,無法重復(fù)使用。

更多有關(guān)Alzet滲透泵工作原理的介紹,請聯(lián)系北京百奧創(chuàng)新科技有限公司獲取。


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