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二硫赤蘚糖醇號：6892-68-8   
英文名稱：DTE；DL-Dithioerythritol；erythro-1,4-Dimercapto-2,3-butanediol；Cleland’s reagent    
其他名稱：二硫代赤蘚糖醇；1，4-二硫代赤蘚糖醇；二硫赤蘚醇；二硫基赤蘚糖醇；二硫代赤丁四醇；1,4-二巰基-2,3-丁二醇；二硫代赤蘚醇；二硫赤色草醇    
號：6892-68-8    
C4H10O2S2=154.25   
級別：BR   
含量：≥99.0%   
熔點：81～85℃   
性狀(以下信息僅供參考)：白色結(jié)晶性粉末，溶于水   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)還原巰基或二硫鍵的試劑。二硫赤蘚糖醇和二硫蘇糖醇是互為同分異構(gòu)體，同時又被稱作克萊蘭氏試劑(Cleland’s reagent)。它們都具有保護(hù)巰基(-SH)免遭氧化、同時也可使二硫化合物定量地還原成巰基的作用，是切斷蛋白質(zhì)中二硫鍵的主要生化試劑   
保存：-20℃二硫赤蘚糖醇號：6892-68-8儲存條件：
避光、干燥陰涼處封閉貯存,嚴(yán)禁與有毒、有害物品混放、混運。本品為非危險 產(chǎn)品可按一般化學(xué)品運輸,輕搬動輕放,防止日曬、雨淋！受熱、受潮、受光后易喪失活力,保存期短,因此貯存和運輸條件比較苛刻。
運輸：汽車運輸、EMS郵政快遞，申通快遞等， 款到上海3天內(nèi)發(fā)貨；
售后：如您對我們的產(chǎn)品服務(wù)及技術(shù)指標(biāo)有特殊要求，請及時通知我方。
存儲：應(yīng)貯存在干燥清潔避光的環(huán)境中，嚴(yán)禁與有毒物質(zhì)混放，以免污染（保質(zhì)期為兩年）。
二硫赤蘚糖醇號：6892-68-8主要優(yōu)級純、分級純和化學(xué)純3種：
（1）優(yōu)級純（GR：Guaranteed reagent），又稱一級品或保證試劑，99.8%，這種試劑純度Z高，雜質(zhì)含量Z低，適合于重要精密的分析工作和科學(xué)研究工作，使用綠色瓶簽。
（2）分析純（AR），又稱二級試劑，純度很高，99.7%，略次于優(yōu)級純，適合于重要分析及一般研究工作，使用紅色瓶簽。
（3）化學(xué)純（CP），又稱三級試劑，≥ 99.5%，純度與分析純相差較大，適用于工礦、學(xué)校一般分析工作。使用藍(lán)色（深藍(lán)色）標(biāo)簽。
（4）實驗試劑（LR：Laboratory reagent），又稱四級試劑。
1
產(chǎn)品類型  一抗   
研究領(lǐng)域  細(xì)胞生物 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 
蛋白分子量  predicted molecular weight: 59kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human SRP1/karyopherin alpha 1
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors that mediate protein passage through the nuclear pore complex (NPC). Cytoplasmic proteins that contain nuclear localization signals (NLSs) must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Karyopherin alpha 1 and karyopherin alpha 6 are widely expressed nuclear import proteins that act as adaptors for karyopherin ∫1, specifically binding to and guiding NLS-containing proteins to the NPC. Both karyopherin alpha 1 and karyopherin alpha 6 contain one IBB domain and ten ARM repeats through which they convey their protein binding and localization function. Together, karyopherin ?1 and karyopherin ?6 are responsible for ensuring the nuclear import of NLS-containing substrates
Function : Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Subunit : Heterodimer; with KPNB1. Interacts with ANP32E. Interacts with ZIC3 (By similarity). Interacts with the nucleoprotein of influenza A viruses. Binds to HCMV (human cytomegalovirus) UL84, -1 Vpr and to ebolavirus VP24. Interacts with APEX1 and RAG1. Interacts with CTNNBL1 (via its N-terminal). Interacts with AICDA (via its NLS).
Subcellular Location : Cytoplasm. Nucleus.
Tissue Specificity : Expressed ubiquitously.
Post-translational modifications : Polyubiquitinated in the presence of RAG1 (in vitro).
Similarity : Belongs to the importin alpha family.
Contains 10 ARM repeats.
Contains 1 IBB domain.
Database links : UniProtKB/Swiss-Prot: P52294.3
英文名稱  Anti-FHOD3
中文名稱  FHOD3蛋白抗體
別    名  FLJ22717; Formactin2; FH1/FH2 domain containing protein 3; FH1/FH2 domain-containing protein 3; Fhod3; FHOD3_HUMAN; FHOS2; FLJ22297; FLJ22717; Formactin-2; Formactin2; Formin homolog overexpressed in spleen 2; Formin homology 2 domain containing 3; hFHOS2; KIAA1695; mKIAA1695.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應(yīng)  Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep
產(chǎn)品類型  一抗   
研究領(lǐng)域  細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞骨架 表觀遺傳學(xué) 
蛋白分子量  predicted molecular weight: 159kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Supervillin
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 FHOD3 (formin homology 2 domain containing 3), also known as FHOS2 or KIAA1695, is a 1,422 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one DAD domain, one FH1 domain, one FH2 domain and one GBD/FH3 domain. Expressed in brain, heart and kidney, FHOD3 interacts with intermediate filaments and functions as an Actin-organizing protein that is thought to promote the formation of stress fibers in conjunction with cellular elongation. Multiple isoforms of FHOD3 exist due to alternative splicing events. The gene encoding FHOD3 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic angiectasia, erythropoietic protoporphyria and follicular lymphomas.
Function : Actin-organizing protein that may cause stress fiber formation together with cell elongation.
Subunit : Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding.
Subcellular Location : Cytoplasm; cytoskeleton. Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining.
Tissue Specificity : Expressed in the heart, kidney and brain.
Similarity : Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Database links : UniProtKB/Swiss-Prot: Q2V2M9.2