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化*號：910-31-6   
英文名稱：Cholesteryl chloride；3β-Chloro-5-cholestene   
其他名稱：*化物；3β-3-膽甾-5-烯；化膽甾醇；膽甾醇；膽甾醇酯；硬酯酰   
號：910-31-6   
C27H45Cl=405.10   
級別：BR    
含量：≥98.0%   
熔點：94～97℃   
性狀(以下信息僅供參考)：白色或黃色至褐色粉末或結(jié)晶。   
用途：本品僅供科研，不得用于其它用途   
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 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Stat 5a protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct Stat 5 genes (Stat 5a and Stat 5b) were identified in mouse. The amino acid sequences of Stat 5a and Stat 5b show 96% sequence similarity, and both proteins are co expressed in most tissues of both virgin and lactating mice. However, differential accumulation of Stat 5a and Stat 5b mRNA has been reported for both muscle and mammary tissue. Stat 5a is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.
Function : Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Subunit : Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7. Interacts with ERBB4.
Subcellular Location : Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Post-translational modifications : Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694.
Similarity : Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.
Database links : UniProtKB/Swiss-Prot: P42229.1
英文名稱  Anti-phospho-SYT6(Thr418)
中文名稱  磷酸化突觸蛋白6抗體
別    名  SYT6(phospho T418); Synaptotagmin 6; Synaptotagmin VI; Synaptotagmin-6; Synaptotagmin6; SynaptotagminVI; Syt 6; Syt VI; Syt6; SYT6_HUMAN; SytVI. 
濃    度  1mg/1ml
規(guī) 格  0.1ml/100μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Dog, Pig, Cow, Horse
產(chǎn)品類型  一抗  磷酸化抗體  
研究領(lǐng)域  免疫學 神經(jīng)生物學 信號轉(zhuǎn)導 轉(zhuǎn)運蛋白 細胞類型標志物 
蛋白分子量  predicted molecular weight: 57kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human SYT6 around the phosphorylation site of Thr418
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Synaptotagmins (Syts) are a large gene family of synaptic vesicle integral membrane proteins. Syt functions as regulators of both exocytosis /endocytosis and is involved in neurotransmitter secretion from small secretory vesicles. 13 isoforms of Syt have been identified(SytI-XIII). SynaptotagminVI is localized to the endoplasmic reticulum and/or Golgi like perinuclear compartment. It may be important for trafficking and calcium signaling as it is specially expressed in nonneuronal tissues. Also SytVI is present in the acrosomal region of mammalian spermatozoa. The cytosolic domain of SytVI can abrogate exocytosis by competing with the endogenous protein for essential interactions with the fusion machinery involved in a acrosomal exocytosis.
Function : May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).
Subunit : Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent. Isoform 2 is not able to form homodimer and heterodimers (By similarity).
Subcellular Location : Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity).
Isoform 1: Membrane; Single-pass membrane protein (By similarity). Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity).
Isoform 2: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
Similarity : Belongs to the synaptotagmin family.
Contains 2 C2 domains.
Database links : UniProtKB/Swiss-Prot: Q5T7P8.3
英文名稱  Anti-phospho-STAT5a(Tyr694)
中文名稱  磷酸化信號轉(zhuǎn)導和轉(zhuǎn)錄激活因子5a抗體
別    名  p-STAT5a(Tyr694); STAT5A(phospho Y694); Mammary gland factor; Mammary gland factor; MGF; MGF; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5A; STA5A_HUMAN; STAT 5; STAT 5A; STAT5; STAT5A.
濃    度  1mg/1ml
規(guī) 格  0.1ml/100μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep
產(chǎn)品類型  一抗  磷酸化抗體  
研究領(lǐng)域  染色質(zhì)和核信號 信號轉(zhuǎn)導 表觀遺傳學 
蛋白分子量  predicted molecular weight: 91kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human STAT5a around the phosphorylation site of Tyr694
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500