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偶氮膦mN  號：77350-04-0 
英文名稱：CPA-mN；Chlorophosphonazo mN    
其他名稱：2-(4--2-膦酸基苯偶氮)-7-(3-硝基苯偶氮)-1,8-二羥基萘-3,6-二磺酸   
號：77350-04-0   
C22H15ClN5O13PS2=687.94    
級別：顯色劑   
對稀土金屬靈敏度試驗：合格   
吸光度試驗：合格   
性狀(以下信息僅供參考)：深紫紅色粉末。溶于水   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)與稀土元素在酸性溶液中形成藍紫色絡合物。用于球墨鑄鐵中稀土的測定   
保存：RT 客戶根據(jù)偶氮膦mN 號：77350-04-0性質(zhì)、化學式、分子式、結構式、比重、密度、號、沸點、熔點、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項、英文名、別稱、純度、級別等情況，本產(chǎn)品化學性質(zhì)穩(wěn)定，運輸條件不苛刻，一般儲存在陰涼，干燥，通風良好的地方，遠離不相容的物質(zhì)。保持容器密閉。
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級別：GR級別、AR級別、CP級別、L.P.級別等
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(PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
Subunit : Interacts with MAVS.
Subcellular Location : Mitochondrion outer membrane.
Tissue Specificity : Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
Similarity : Belongs to the NLRP family.
Contains 7 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
Database links : UniProtKB/Swiss-Prot: Q86UT6.1
英文名稱  Anti-NCKAP1/NAP125
中文名稱  膜相關的蛋白質(zhì)HEM2抗體
別    名  NCK associated protein 1; NCK associated protein 1; Membrane associated protein HEM2; Membrane-associated protein HEM-2; NAP 1; NAP1; NAP125; NCK associated protein; Nck-associated protein 1; Nckap1; NCKP1_HUMAN; p125Nap1.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
偶氮膦mN 號：77350-04-0抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, G 
產(chǎn)品類型  一抗   
研究領域  腫瘤 細胞生物 神經(jīng)生物學 信號轉導 細胞凋亡 轉錄調(diào)節(jié)因子 
蛋白分子量  predicted molecular weight: 129kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human 12 NCKAP1
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產(chǎn)品應用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 NAP125, also known as NCKAP1 (NCK-associated protein 1), p125Nap1 or membrane-associated protein HEM-2, is a 1,128 amino acid single pass membrane protein that exists as two alternatively spliced isoforms and belongs to the HEM-1/HEM-2 family. While widely expressed, NAP125 is found at highest levels in heart, brain and skeletal muscle where it regulates Rac-dependent actin remodeling as part of a lamellipodial complex with WAVE2, Abi-1 and CYFIP1. NAP125 localizes to the cytoplasmic side of lamellipodium membrane and is encoded by a gene that maps to human chromosome 2q32.1 and mouse chromosome 2 C3. NAP125 expression is markedly reduced in Alzheimer disease (AD)-affected brains, suggesting a possible role in the disease.
Function : Is part of lamellipodial complex that controls Rac-dependent actin remodeling.Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.
Subcellular Location : Cell membrane. Cell projection
Tissue Specificity : Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.