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甲基紫號：8004-87-3   
英文名稱：Methyl violet；Dahlia B；Basic violet 1；Pyrokatanium blue；C.I.42535     
其他名稱：甲基青蓮；堿性紫1；甲基紫2B；苯胺紫；堿性紫1；甲紫；堿基青蓮；堿性紫2B    
號：8004-87-3    
C24H28ClN3=393.95   
級別：BS   
生物染色試驗：合格   
pH變色域：pH 0.13(黃色)～0.5(綠色)； pH 1.0(綠色)～1.5(藍色)； pH 2.0(藍色)～3.2(紫色)    
性狀(以下信息僅供參考)：綠色有光澤的結(jié)晶性粉末。為副品紅堿的四甲基、五甲基、六甲基衍生物的混合物，其中以五甲基衍生物為主(分子式、分子量即指此種衍生物)。溶于水和乙醇，呈紫色溶液，溶于甘油和方，幾乎不溶于乙迷。熔點137℃(分解)。Z大吸收波長584nm。   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)光度測定鋅、鎘、汞、銻、駝、金等和沉淀鋅、鎘和銻。酸堿指示劑，生物染色劑   
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diagnostic applications.
產(chǎn)品介紹 Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.
Function : CCRN4L is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.
Similarity : Belongs to the CCR4/nocturin family.
Database links : UniProtKB/Swiss-Prot: Q9UK39.2
英文名稱  Anti-NR0B2/SHP
中文名稱  核受體0相關(guān)蛋白B家族2抗體
別    名  NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0, group B, member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
甲基紫號：8004-87-3交叉反應(yīng)  Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
產(chǎn)品類型  一抗   
研究領(lǐng)域  腫瘤 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) 
蛋白分子量  predicted molecular weight: 28kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NR0B2
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應(yīng)用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復(fù)）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 SHP is an orphan nuclear receptor containing the dimerization and ligand-binding domains found in other nuclear receptors, but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues, including fetal liver and adrenal gland, as well as adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARg. SHP interacts with nuclear receptors, including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function through competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NFkB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NFkB. Lastly, negative feedback regulation of a hepatic bile acid transporter, NTCP, is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.