Anti-TIE1抗體,血管生成素受體1抗體說明書產(chǎn)品介紹：TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximay 107 kDa. Due to glycosylation, the protein migrates to approximay 160 kDa in SDS PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium. 

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保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
連續(xù)使用時4°C存儲，保質(zhì)期六個月，*存儲時建議分裝為10ul以上小包裝-20°C存儲，并避免反復凍融，保質(zhì)期一年。

產(chǎn)品名稱 Anti-TIE1抗體,血管生成素受體1抗體說明書

產(chǎn)品編號 BYK-1334R

英文名稱 TIE1
中文名稱 血管生成素受體1抗體
別    名 TIE1_HUMAN; JKT 14; JTK14; TIE; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains; Tyrosine protein kinase receptor Tie 1; Tyrosine-protein kinase receptor Tie-1; tyrosine kinase receptor 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1.
研究領(lǐng)域 腫瘤  心血管  信號轉(zhuǎn)導  干細胞  生長因子和激素    

抗體來源 Rabbit or Mouse
克隆類型 Polyclonal or Monoclonal
交叉反應、產(chǎn)品應用 （具體交叉反應與產(chǎn)品應用請）

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