Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

別名：AAG6; Aging associated gene 6; KPCA_HUMAN; MGC129900; MGC129901; PICK 1; PKC A; PKC alpha; PKC alpha; PKC-A; PKC-alpha; PKCA; PRKACA; PRKC A; PRKCA; Protein Kinase C alpha; Protein kinase C alpha type. 

蛋白激酶C α抗體,Anti-PKC alpha抗體簡單介紹：

產(chǎn)品編號：BYK-3531R

英文名稱：Anti-PKC alpha
中文名稱：蛋白激酶C α抗體

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

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性    狀 Lyophilized or Liquid
濃    度 1mg/ml

蛋白激酶C α抗體,Anti-PKC alpha抗體產(chǎn)品信息：

博研生物小課堂：

常用激光器對應熒光素的選擇：

藍色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

功能區(qū)的作用：

（1）VL和VH：結合抗原決定簇（FV區(qū)）

（2）CL和CH：具有同種異型的遺傳標記

（3）CH2：結合補體

（4）CH3：結合Fc受體

抗原結合點由L鏈和H鏈超變區(qū)組成，與相應抗原上的表位互補，借助靜電力，氫鍵以及范德華力等次級鍵相結合。

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