背景介紹：Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

別名：APP beta secretase; Asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE; Beta secretase 1; Beta secretase; Beta site amyloid beta A4 precursor protein cleaving enzyme; Beta site amyloid precursor protein cleaving enzyme 1; Beta site amyloid precursor protein cleaving enzyme; Beta site APP cleaving enzyme 1; Beta site APP cleaving enzyme; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Memapsin 2; Memapsin2; Membrane associated aspartic protease 2; Transmembrane aspartic proteinase Asp2; BACE1_HUMAN; Beta-secretase 1; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Membrane-associated aspartic protease 2.  

β分泌酶抗體,Anti-BACE1抗體簡單介紹：

產(chǎn)品編號：BYK-0164R

英文名稱：Anti-BACE1
中文名稱：β分泌酶抗體

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請或添加客服直接索取）

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

β分泌酶抗體,Anti-BACE1抗體產(chǎn)品信息：

博研生物小課堂：

常用激光器對應(yīng)熒光素的選擇：

藍(lán)色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

構(gòu)象決定簇(conformational determinants),又稱為不連續(xù)決定簇(discontinuous determinants),抗原分子中由分子基團(tuán)間特定的空間構(gòu)象決定的決定簇,一般是由分子中不連續(xù)的若干肽鏈盤繞折疊而構(gòu)成。

順序決定簇(sequential determinants),又稱為連續(xù)決定簇(continuous determinants),抗原分子中直接由分子基團(tuán)的一級結(jié)構(gòu)序列決定的決定簇。

一般來講,二種決定簇都依賴于多肽鏈上的某一段氨基酸序列,空間構(gòu)象也是由一級序列決定的。因此決定簇都依賴于空間構(gòu)象和氨基酸序列兩種因素。

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