背景介紹：Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

別名：bFGF R; BFGFR; C FGR; CD 331; CD331; CD331 antigen; CEK; FGFBR; FGFR 1; Fibroblast growth factor receptor 1; FLG; FLG protein; FLJ14326; FLT 2; FLT2; Fms like tyrosine kinase 2; Fms related tyrosine kinase 2; Fms related tyrosine kinase 2 Pfeiffer syndrome; H2; H3; H4; H5; HBGFR; Heparin binding growth factor receptor; Hydroxyaryl protein kinase; KAL 2; KAL2; MFR; N SAM; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Basic fibroblast growth factor receptor 1; FGFR1_HUMAN.

堿性成纖維細胞生長因子受體1,FGFR1抗體簡單介紹：

產(chǎn)品編號：BYK-20226R

英文名稱：Anti-FGFR1
中文名稱：堿性成纖維細胞生長因子受體1抗體

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應、產(chǎn)品應用 （具體交叉反應與產(chǎn)品應用請或添加客服直接索?。?/span>

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

堿性成纖維細胞生長因子受體1,FGFR1抗體產(chǎn)品信息：

博研生物小課堂：

常用激光器對應熒光素的選擇：

藍色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

構(gòu)象決定簇(conformational determinants),又稱為不連續(xù)決定簇(discontinuous determinants),抗原分子中由分子基團間特定的空間構(gòu)象決定的決定簇,一般是由分子中不連續(xù)的若干肽鏈盤繞折疊而構(gòu)成。

順序決定簇(sequential determinants),又稱為連續(xù)決定簇(continuous determinants),抗原分子中直接由分子基團的一級結(jié)構(gòu)序列決定的決定簇。

一般來講,二種決定簇都依賴于多肽鏈上的某一段氨基酸序列,空間構(gòu)象也是由一級序列決定的。因此決定簇都依賴于空間構(gòu)象和氨基酸序列兩種因素。

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