背景介紹：Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identifiedand designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

別名：BAG 4; BAG family molecular chaperone regulator 4; BAG-4; BAG4; BAG4_HUMAN; Bcl 2 associated athanogene 4; Bcl-2-associated athanogene 4; BCL2 associated athanogene 4; Silencer of death domains; SODD.

Bcl2結合抗凋亡蛋白4抗體，Anti-SODD抗體簡單介紹：

產品編號：BYK-10774R

英文名稱：Anti-SODD
中文名稱：Bcl2結合抗凋亡蛋白4抗體

產品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應、產品應用 （具體交叉反應與產品應用請或添加客服直接索取）

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

Bcl2結合抗凋亡蛋白4抗體，Anti-SODD抗體產品信息：

博研生物小課堂：

常用激光器對應熒光素的選擇：

藍色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

1.陽性細胞染色分布有三種類型：細胞漿、細胞核、細胞膜表面。大部分抗原見于細胞漿，可見于整個胞漿或部分胞漿

2.陽性細胞分布可分為灶型和彌漫性

3.由于細胞內含抗原量不同，所以染色強度不一。如果細胞之間染色強度相同，常提示其反應為非特異性

4.陽性細胞染色定位于單個細胞，且與陰性細胞相互交雜分布；而非特異性染色常不限于單個細胞，而是累及一片細胞。

5.切片邊緣、刀痕或褶皺區(qū)域，壞死或擠壓的細胞區(qū)，膠原結締組織等，常表現為相同的陽性染色強度，不能用于判斷陽性。

Bcl2結合抗凋亡蛋白4抗體，Anti-SODD抗體相關產品：

Anti-Neurocan 神經粘蛋白抗體
Anti-Laminin alpha 4 層粘蛋白α4抗體(Lamininα4)
Anti-Nrn1/Cpg15/Neuritin 轉化神經突起蛋白抗體
Anti-COPA/alpha COP I COPA蛋白抗體
Anti-TAS2R9  味覺受體蛋白家族2亞基9抗體
Anti-NeuN/Fox 3 神經元核抗原抗體
Anti-RGMA 反義導向分子RGMA抗體
Anti-AKAP95/AKAP8 蛋白激酶A錨定蛋白95抗體
Anti-Neurobeachin 蛋白激酶錨定蛋白抗體
Anti-Nestin 巢蛋白/神經上皮干細胞蛋白抗體
Anti-Claudin 1 緊密連接蛋白1抗體
Anti-CTLA-4/CD152 細胞毒性T細胞抗原4抗體
Anti-Nectin 2/CD112 細胞粘附分子CD112抗體
Anti-Nephrin 腎小球細胞粘附分子受體抗體
Anti-UCHL3 泛素硫酯酶L3抗體