背景介紹：MUS81 encodes a helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae (1). Mus81 is important for replicational stress tolerance in both budding and fission yeast (2). Specifically, Mus81 associates with Eme1 to form an endonuclease that can process stalled replication forks before they have regressed to form a Holliday junction (2–4). Mus81 associated endonuclease resolves Holliday junctions into linear duplexes by cutting across the junction exclusively on strands of like polarity (2). In addition, Mus81 protein abundance increases in cells following exposure to agents that block DNA replication (2). Mus81 is involved in the recruitment of Cds1 to aberrant DNA structures where Cds1 modulates the activity of damage tolerance enzymes (4). The gene encoding human MUS81 maps to chromosome 11q13 and encodes a 551 amino acid protein (5).

別名：Crossover junction endonuclease MUS81; FLJ21012; FLJ44872; Mus 81; MUS81; MUS81 Endonuclease Homolog; MUS81_HUMAN.  

核酸內(nèi)切酶同源蛋白抗體，Anti-Mus81抗體簡單介紹：

產(chǎn)品編號：BYK-19109R

英文名稱：Anti-Mus81
中文名稱：核酸內(nèi)切酶同源蛋白抗體

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請或添加客服直接索取）

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

核酸內(nèi)切酶同源蛋白抗體，Anti-Mus81抗體產(chǎn)品信息：

博研生物小課堂：

常用激光器對應(yīng)熒光素的選擇：

藍色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

顯色觀察

免疫酶染色應(yīng)注意控制：

1. 呈色質(zhì)濃度和反應(yīng)時間。增加成色質(zhì)的量和（或）增加底物反應(yīng)時間，可增加反應(yīng)產(chǎn)物強度；著色太深可減少反應(yīng)時間。

2. 過氧化物酶顯色時，H2O2濃度較大將使顯色反應(yīng)過快而至背景加深；過量H2O2可能抑制酶的活性。

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