背景介紹：This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. 

Function:
Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimay induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (Ref.13). Has also been shown to inhibit IL1B production (Ref.14, Ref.15). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization.

別名：FMF; Marenostrin; Mediterranean fever; Mediterranean fever protein; MEF; Mefv; MEFV_HUMAN; Pyrin; TRIM20. 

地中海熱蛋白MEFV抗體,Anti-MEFV抗體簡單介紹：

產(chǎn)品編號(hào)：BYK-18750R

英文名稱：Anti-MEFV
中文名稱：地中海熱蛋白MEFV抗體

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)或添加客服直接索?。?/span>

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

地中海熱蛋白MEFV抗體,Anti-MEFV抗體產(chǎn)品信息：

博研生物小課堂：

常用激光器對(duì)應(yīng)熒光素的選擇：

藍(lán)色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7

紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647

黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594

流式細(xì)胞術(shù)Flowcytometry：理：流式細(xì)胞術(shù)(flowcytometry FCM)是對(duì)單個(gè)細(xì)胞或其他生物微粒進(jìn)行快速定量分析和分選的一門技術(shù)。在分析或分選過程中，包繞在流動(dòng)液體中處理過的單個(gè)細(xì)胞或微粒通過聚焦的光源，產(chǎn)生電信號(hào)，這些信號(hào)代表光散射、熒光等參數(shù)，以此測(cè)定出細(xì)胞或微粒的物理和化學(xué)性質(zhì)，并可根據(jù)這些性質(zhì)分選出高純度的細(xì)胞亞群，以對(duì)其進(jìn)一步的培養(yǎng)或分析。

應(yīng)用：流式細(xì)胞術(shù)的功能決定了其在免疫學(xué)基礎(chǔ)研究中的廣泛應(yīng)用，目前在臨床上主要用于細(xì)胞表型分析、造血系腫瘤診斷和分型、移植前配型及與免疫有關(guān)疾病分析等。

地中海熱蛋白MEFV抗體,Anti-MEFV抗體相關(guān)產(chǎn)品：

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