法尼基二磷酸轉(zhuǎn)移酶1抗體，Anti-FDFT1抗體簡(jiǎn)單介紹：

產(chǎn)品編號(hào)：BYK-10745R

英文名稱：Anti-FDFT1
中文名稱：法尼基二磷酸轉(zhuǎn)移酶1抗體

別名：DGPT; ERG9; Farnesyl diphosphate farnesyltransferase 1; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT_HUMAN; FDFT1; FPP:FPP farnesyltransferase; Presqualene di diphosphate synthase; SQS; Squalene synthase; Squalene synthetase; SS.  

背景介紹：Several proteins mediate the biosynthesis of cholesterol. The first specific step in the cholesterol biosynthetic pathway is the conversion of transfarnesyl-diphosphate to Squalene, which is catalyzed by the endoplasmic reticulum membrane-associated enzyme Squalene synthetase, also designated Squalene synthase and Farnesyl-diphosphate farnesyltransferase. Squalene synthetase is located at a branch point in the mevalonate pathway and is also involved in isoprenoid biosynthesis. Squalene epoxidase, also designated Squalene monooxygenase, is a multi-pass microsomal membrane-associated enzyme that catalyzes the first oxygenation step in sterol biosynthesis and most likely functions as one of the rate-limiting enzymes in this pathway. Squalene epoxidase may form a complex with Squalene synthetase.

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來(lái)源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)或添加客服直接索?。?/span>

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

法尼基二磷酸轉(zhuǎn)移酶1抗體，Anti-FDFT1抗體產(chǎn)品信息：

合適的抗體稀釋度

抗體的濃度是免疫染色的關(guān)鍵，如果抗體濃度過(guò)高，抗體分子過(guò)多于抗原決定簇，可導(dǎo)致抗體結(jié)合減少，產(chǎn)生陰性結(jié)果。此陰性結(jié)果并不一定是缺少抗原，而是由于抗體過(guò)量，這種現(xiàn)象類似于凝集反應(yīng)中的前帶效應(yīng)（prozone effect）。因此，必須使用一系列稀釋做“棋盤式效價(jià)滴定”，檢測(cè)抗體的合適稀釋度，以得到zui大強(qiáng)度的特異性染色和zui弱的背景染色?？贵w稀釋度應(yīng)根據(jù)：1.抗體效價(jià)高，溶液中特異性抗體濃度越高，工作稀釋度越高；2.一般講，應(yīng)用的抗體稀釋度越大，溫育時(shí)間越長(zhǎng)；3.對(duì)于抗體與非特異性蛋白的結(jié)合，只有高稀釋度時(shí)才能防止其非特異性背景染色；4.稀釋用緩沖液的種類，標(biāo)本的固定和處理過(guò)程等也可影響稀釋度，所以合適的稀釋度應(yīng)根據(jù)具體情況測(cè)定。抗體的稀釋主要是指*抗體，因?yàn)?抗體中特異性抗體合適的濃度是關(guān)鍵，應(yīng)用高稀釋度*抗體僅高親和力的特異性染色反應(yīng)，減少或消除其中交叉抗體反應(yīng)。

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