凝集素甘露糖結(jié)合蛋白2樣蛋白抗體,VIPL抗體簡單介紹：

產(chǎn)品編號：BYK-18307R

英文名稱：Anti-VIPL
中文名稱：凝集素甘露糖結(jié)合蛋白2樣蛋白抗體

別名：DKFZp564L2423; Lectin mannose-binding 2-like; lectin, mannose binding 2 like; LMA2L_HUMAN; LMAN2 like protein; LMAN2-like protein; LMAN2L; MGC11139; VIP36 like protein [Precursor]; VIP36-like protein; VIPL. 

背景介紹：Lectin mannose-binding 1, also designated vesicular integral-membrane protein (VIP36), and lectin mannose-binding 2, also designated ERGIC-53, comprise a family of membrane bound, ubiquitously expressed proteins involved in the selective transport of newly synthesized glycoproteins from the endoplasmic reticulum to the ER-Golgi intermediate compartment. VIPL (VIP36-like protein), also known as LMAN2L (lectin, mannose-binding 2-like), is a 348 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and Golgi apparatus. Containing one L-type lectin-like domain, VIPL is highly expressed in skeletal muscle and kidney, and is found at intermediate levels in heart, liver and placenta, and low levels in brain, thymus, spleen, small intestine and lung. VIPL is suggested to be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. VIPL may function as a regulator of ERGIC-53. VIPL exists a two alternatively spliced isoforms. 

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

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性    狀 Lyophilized or Liquid
濃    度 1mg/ml

凝集素甘露糖結(jié)合蛋白2樣蛋白抗體,VIPL抗體產(chǎn)品信息：

免疫應(yīng)答

    抗原刺激機體產(chǎn)生相應(yīng)的抗體，抗體的產(chǎn)生過程即為體液免疫應(yīng)答過程。

    體液免疫應(yīng)答的主要*位是淋巴結(jié)、脾臟和粘膜下淋巴組織等外周免疫器官，外來抗原進入機體后即被補體致敏或者被DC吞噬，然后隨淋巴液進入引流淋巴結(jié)。淋巴濾泡中的FDC通過其表面的補體受體捕獲被致敏的外來抗原，激活B細(xì)胞。位于脾髓質(zhì)交界區(qū)的DC則為T細(xì)胞呈遞外來抗原肽，啟動獲得性免疫應(yīng)答，B細(xì)胞在外周成熟、發(fā)育過程的zui后階段是成為專門的合成和分泌抗體分子的漿細(xì)胞。漿細(xì)胞高爾基體發(fā)達、代謝活躍，但沒有繼續(xù)分裂、增殖的能力，也不參與抗原遞呈。他們寄居在脾臟或者骨髓中，集中所有的能量生產(chǎn)并分泌抗體分子?？贵w分子的重鏈和輕鏈在內(nèi)質(zhì)網(wǎng)上合成、組裝后經(jīng)高爾基體運輸至細(xì)胞表面并分泌于胞外。一個漿細(xì)胞每秒鐘能分泌5000個抗體分子，在外周的漿細(xì)胞壽命僅為幾天，但是骨髓中的漿細(xì)胞壽命可能較長。

免疫應(yīng)答過程：

1.抗原進入機體；

2.抗原刺激 B淋巴細(xì)胞，使之分化增殖成為抗體分泌漿細(xì)胞和記憶細(xì)胞（初次免疫應(yīng)答）；

3.抗體主要由漿細(xì)胞分泌 ；

4.記憶細(xì)胞再次受到特異性抗原刺激后會被激活而成為分泌抗體的漿細(xì)胞（再次免疫應(yīng)答）；

5.記憶B細(xì)胞是長命細(xì)胞，可以存活數(shù)月甚至機體終生

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