脂多糖誘導(dǎo)腫瘤壞死因子α抗體,LITAF抗體簡(jiǎn)單介紹：

產(chǎn)品編號(hào)：BYK-18300R

英文名稱：Anti-LITAF
中文名稱：脂多糖誘導(dǎo)腫瘤壞死因子α抗體

別名：Lipopolysaccharide induced TNF alpha factor; CMT1C; FLJ38636; Lipopolysaccharide induced TNF alpha factor; Lipopolysaccharide induced TNF factor; Lipopolysaccharide induced tumor necrosis factor alpha factor; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; LITAF; LITAF_HUMAN; LPS induced TNF alpha factor; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276; p53 induced gene 7 protein; p53-induced gene 7 protein; PIG 7; PIG7; SIMPLE; Small integral membrane protein of lysosome/late endosome; TP53I7; Tumor protein p53 inducible protein 7.  

背景介紹：Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)或添加客服直接索?。?/span>

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

脂多糖誘導(dǎo)腫瘤壞死因子α抗體,LITAF抗體產(chǎn)品信息：

免疫應(yīng)答

    抗原刺激機(jī)體產(chǎn)生相應(yīng)的抗體，抗體的產(chǎn)生過程即為體液免疫應(yīng)答過程。

    體液免疫應(yīng)答的主要*位是淋巴結(jié)、脾臟和粘膜下淋巴組織等外周免疫器官，外來抗原進(jìn)入機(jī)體后即被補(bǔ)體致敏或者被DC吞噬，然后隨淋巴液進(jìn)入引流淋巴結(jié)。淋巴濾泡中的FDC通過其表面的補(bǔ)體受體捕獲被致敏的外來抗原，激活B細(xì)胞。位于脾髓質(zhì)交界區(qū)的DC則為T細(xì)胞呈遞外來抗原肽，啟動(dòng)獲得性免疫應(yīng)答，B細(xì)胞在外周成熟、發(fā)育過程的zui后階段是成為專門的合成和分泌抗體分子的漿細(xì)胞。漿細(xì)胞高爾基體發(fā)達(dá)、代謝活躍，但沒有繼續(xù)分裂、增殖的能力，也不參與抗原遞呈。他們寄居在脾臟或者骨髓中，集中所有的能量生產(chǎn)并分泌抗體分子?？贵w分子的重鏈和輕鏈在內(nèi)質(zhì)網(wǎng)上合成、組裝后經(jīng)高爾基體運(yùn)輸至細(xì)胞表面并分泌于胞外。一個(gè)漿細(xì)胞每秒鐘能分泌5000個(gè)抗體分子，在外周的漿細(xì)胞壽命僅為幾天，但是骨髓中的漿細(xì)胞壽命可能較長(zhǎng)。

免疫應(yīng)答過程：

1.抗原進(jìn)入機(jī)體；

2.抗原刺激 B淋巴細(xì)胞，使之分化增殖成為抗體分泌漿細(xì)胞和記憶細(xì)胞（初次免疫應(yīng)答）；

3.抗體主要由漿細(xì)胞分泌 ；

4.記憶細(xì)胞再次受到特異性抗原刺激后會(huì)被激活而成為分泌抗體的漿細(xì)胞（再次免疫應(yīng)答）；

5.記憶B細(xì)胞是長(zhǎng)命細(xì)胞，可以存活數(shù)月甚至機(jī)體終生

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