硫辛酰胺脫氫酶抗體,Anti-DLDD抗體簡(jiǎn)單介紹：

產(chǎn)品編號(hào)：BYK-18295R

英文名稱：Anti-DLDD
中文名稱：硫辛酰胺脫氫酶抗體

別名：Dehydrogenase complex, E3 component; Diaphorase; Dihydrolipoamide dehydrogenase; Dihydrolipoyl dehydrogenase; Dihydrolipoyl dehydrogenase mitochondrial; dld; DLDD; DLDH; DLDH_HUMAN; E3; E3 branched chain aplha-keto acid; E3 component of pyruvate dehydrogenase; E3 component of pyruvate dehydrogenase complex 2 oxo glutarate complex branched chain keto acid dehydrogenase complex; GCSL; Glycine cleavage system L protein; Glycine cleavage system protein L; LAD; lipoamide dehydrogenase; Lipoamide reductase; Lipoyl dehydrogenase; mitochondrial; OTTHUMP00000206744; OTTHUMP00000206746; OTTHUMP00000206748; OTTHUMP00000206749; PHE 3; PHE3; Pyruvate dehydrogenase component E3. 

背景介紹：This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants.

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來(lái)源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

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性    狀 Lyophilized or Liquid
濃    度 1mg/ml

硫辛酰胺脫氫酶抗體,Anti-DLDD抗體產(chǎn)品信息：

免疫應(yīng)答

    抗原刺激機(jī)體產(chǎn)生相應(yīng)的抗體，抗體的產(chǎn)生過(guò)程即為體液免疫應(yīng)答過(guò)程。

    體液免疫應(yīng)答的主要*位是淋巴結(jié)、脾臟和粘膜下淋巴組織等外周免疫器官，外來(lái)抗原進(jìn)入機(jī)體后即被補(bǔ)體致敏或者被DC吞噬，然后隨淋巴液進(jìn)入引流淋巴結(jié)。淋巴濾泡中的FDC通過(guò)其表面的補(bǔ)體受體捕獲被致敏的外來(lái)抗原，激活B細(xì)胞。位于脾髓質(zhì)交界區(qū)的DC則為T細(xì)胞呈遞外來(lái)抗原肽，啟動(dòng)獲得性免疫應(yīng)答，B細(xì)胞在外周成熟、發(fā)育過(guò)程的zui后階段是成為專門的合成和分泌抗體分子的漿細(xì)胞。漿細(xì)胞高爾基體發(fā)達(dá)、代謝活躍，但沒(méi)有繼續(xù)分裂、增殖的能力，也不參與抗原遞呈。他們寄居在脾臟或者骨髓中，集中所有的能量生產(chǎn)并分泌抗體分子?？贵w分子的重鏈和輕鏈在內(nèi)質(zhì)網(wǎng)上合成、組裝后經(jīng)高爾基體運(yùn)輸至細(xì)胞表面并分泌于胞外。一個(gè)漿細(xì)胞每秒鐘能分泌5000個(gè)抗體分子，在外周的漿細(xì)胞壽命僅為幾天，但是骨髓中的漿細(xì)胞壽命可能較長(zhǎng)。

免疫應(yīng)答過(guò)程：

1.抗原進(jìn)入機(jī)體；

2.抗原刺激 B淋巴細(xì)胞，使之分化增殖成為抗體分泌漿細(xì)胞和記憶細(xì)胞（初次免疫應(yīng)答）；

3.抗體主要由漿細(xì)胞分泌 ；

4.記憶細(xì)胞再次受到特異性抗原刺激后會(huì)被激活而成為分泌抗體的漿細(xì)胞（再次免疫應(yīng)答）；

5.記憶B細(xì)胞是長(zhǎng)命細(xì)胞，可以存活數(shù)月甚至機(jī)體終生

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