磷脂酰肌醇3磷酸激酶5Ⅲ型抗體,PIP5K3抗體簡單介紹：

產(chǎn)品編號：BYK-18540R

英文名稱：Anti-PIP5K3
中文名稱：磷脂酰肌醇3磷酸激酶5Ⅲ型抗體

別名：1-phosphatidylinositol-3-phosphate 5-kinase; 1 phosphatidylinositol 3 phosphate 5 kinase; 1 phosphatidylinositol 4 phosphate 5 kinase; CFD; FAB1; FYVE finger containing phosphoinositide kinase; KIAA0981; MGC40423; p235; Phosphatidylinositol 3 phosphate 5 kinase type III; Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III; Phosphatidylinositol 4 phosphate 5 kinase type III; Phosphoinositide kinase, FYVE finger containing; PIKFYVE; PIP5K; PIPkin III; PtdIns(4)P 5 kinase; Type III PIP kinase; ZFYVE29; Zinc finger, FYVE domain containing 29. 

背景介紹：Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請或添加客服直接索取）

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

磷脂酰肌醇3磷酸激酶5Ⅲ型抗體,PIP5K3抗體產(chǎn)品信息：

初次體液免疫是指宿主*次接觸外來TD抗原后血清中逐漸出現(xiàn)抗原特異性抗體的過程。初次體液免疫應(yīng)答的延遲相（從抗原免疫到抗體水平達(dá)到高峰的時間）為6-10天，起初幾天血清中的抗原特異性抗體主要為親和力較低的IgM,后期以IgG為主。初次應(yīng)答過程的血清中抗原特異性抗體的高峰濃度較低且維持時間較短。再次體液免疫應(yīng)答是指曾被某抗原免疫過的宿主再次接觸該抗原時血清中迅速出現(xiàn)抗原特異性抗體的過程，其延遲相僅為4-5天，血清抗體以IgG為主，其高峰濃度較高且維持時間較長。再次應(yīng)答所產(chǎn)生的抗體還有親和力成熟現(xiàn)象，即該抗體與抗原的親和力明顯高于初次應(yīng)答產(chǎn)生的抗體。

免疫應(yīng)答過程：

1.抗原進(jìn)入機體；

2.抗原刺激 B淋巴細(xì)胞，使之分化增殖成為抗體分泌漿細(xì)胞和記憶細(xì)胞（初次免疫應(yīng)答）；

3.抗體主要由漿細(xì)胞分泌 ；

4.記憶細(xì)胞再次受到特異性抗原刺激后會被激活而成為分泌抗體的漿細(xì)胞（再次免疫應(yīng)答）；

5.記憶B細(xì)胞是長命細(xì)胞，可以存活數(shù)月甚至機體終生

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