組蛋白乙酰轉(zhuǎn)移酶MOF抗體，Anti-MYST1抗體簡單介紹：

產(chǎn)品編號：BYK-10553R

英文名稱：Anti-MYST1
中文名稱：組蛋白乙酰轉(zhuǎn)移酶MOF抗體

別名：EC 2.3.1.48; Histone acetyltransferase KAT8; Histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; KAT 8; Lysine acetyltransferase 8; MOF; MOZ; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST 1; MYST histone acetyltransferase 1; myst protein 1; MYST-1; MYST1; MYST1_HUMAN; Ortholog of Drosophila males absent on the first (MOF); Probable histone acetyltransferase MYST1; SAS2 and TIP60 protein 1; SAS2; SAS3; TIP60 protein 1; YBF2; YBF2/SAS3.  

背景介紹：Dosage compensation ensures that males with a single X chromosome and females with two X chromosomes have the same amount of most X-linked gene products. In Drosophila, this is acheived by enhancing the level of transcription of the X chromosome in males. Proteins such as maleless, male specific lethal 1, 2 and 3, and males absent on the first (MOF) form a dosage compensation complex (DCC) that is required for the twofold increase of transcription of the male X chromosome. The DCC is preferentially associated with many sites on the X chromosome in somatic cells of males. The binding of the DCC to the X chromosome is dependent upon histone 4 acetylation at lysine 16, which is accomplished by MOF. In mammals, MOF (also designated hMOF, MYST1, or MOZ) belongs to the MYST family of histone acetyl transferases which are characterized by a unique C2HC-type zinc finger close to their HAT domains. MOF utilizes the zinc finger domain to contact the globular part of the nucleosome as well as the histone H4 N-terminal tail substrate. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone acetyltransferases.

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

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性    狀 Lyophilized or Liquid
濃    度 1mg/ml

組蛋白乙酰轉(zhuǎn)移酶MOF抗體，Anti-MYST1抗體產(chǎn)品信息：

冰凍切片的免疫組化染色步驟

- 速凍組織

- 冰凍切片4~8μm，冰凍切片后如不染色，必須吹干，儲存低溫冰箱內(nèi)，或進(jìn)行短暫預(yù)固定后儲存于-20℃冰箱

- 室溫放置30分鐘后，入4℃丙酮固定10分鐘，也可根據(jù)需要選擇其他的固定方式

- PBS沖洗，5分鐘×3次

- 用3%過氧化氫孵育5~10分鐘，消除內(nèi)源性過氧化物酶的活性

- PBS沖洗，5分鐘×3次

- 下接石蠟切片免疫組化染色操作步驟（滴加一抗開始）

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