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背景介紹:This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
英文名稱:Anti-MRVI1
中文名稱:MRVI1蛋白抗體
MRVI1蛋白抗體;Anti-MRVI1抗體簡單介紹:
產(chǎn)品編號:BYK-17837R
別名:Inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; Inositol 145-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase substrate; IRAG; JAW1-related protein MRVI1; JAW1L; Murine retrovirus integration site 1 homolog.
抗體來源 Rabbit or Mouse
克隆類型 Polyclonal or Monoclonal
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分 子 量 96kDa
細胞定位 細胞核 細胞漿
性 狀 Lyophilized or Liquid
濃 度 1mg/ml
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