足底機(jī)械刺痛儀用來評估機(jī)械痛(閾值), “Supertips™” (軟頭) 用來檢測所有的感官閾測試。我們的儀器投入市場已超過十年,是*臺能無污染的準(zhǔn)確檢測并能自動記錄痛閾的儀器。操作方便,設(shè)計緊湊。
設(shè)備特點:
1.適用于小鼠、大鼠、大動物及人
2.可選MRI兼容
3.硬頭可達(dá) 800 Gr.
4.軟頭范圍15 ~75 Gr.
5.防潮
6.隔溫
7.一年質(zhì)保
8.120/240V
- CE認(rèn)證
詳細(xì)說明:
電子Von Frey觸痛儀用來評估機(jī)械痛(閾值), “Supertips™” (軟頭) 用來檢測所有的感官閾測試。2390系列支持研究人員在單體內(nèi)使用三種探針。Von Frey觸痛儀支持多個用戶用一個單體做多個研究。我們的儀器投入市場已超過十年,是*臺能無污染的準(zhǔn)確檢測并能自動記錄痛閾的儀器。操作方便,設(shè)計緊湊。電子Von Frey觸痛儀提供的探針有90g、800 g和1000g三種規(guī)格。探針的類型視實驗對象而定。
硬頭的用于痛閾的實驗;Supertips™用于感觀閾的實驗。本公司的測試絲設(shè)計*——每個軟頭的末端直徑為0.8mm ,可以有效的消除誤讀的情況發(fā)生。(誤讀的原因是由測試絲的薄厚不均造成的)。儀器具有測量、存儲和顯示功能,免除了手算的繁瑣。
實驗簡便:選擇合適的原件放在探針上,插進(jìn)實驗對象,根據(jù)實驗對象的反應(yīng),儀器就能快速的顯示出結(jié)果并儲存。 作為核心原件的內(nèi)置傳感器固定在元件上,并和電子系統(tǒng)相連,以便記錄數(shù)據(jù)。
所有的電子測痛儀已在出廠前校準(zhǔn)完畢,不再需要購買任何的校準(zhǔn)設(shè)備。 模擬輸出線(可選)可提供一個模擬輸出的電壓,它和施加的壓力成正比。信號獨(dú)立,可用于表格記錄或者AD轉(zhuǎn)換器。
電子Von Frey觸痛儀操作簡單方便,改進(jìn)了傳統(tǒng)的槍頭末端,不僅可以進(jìn)行痛閾實驗,同時還可以進(jìn)行感官閾的實驗。
什么是 “Supertips™”
原來的論文撰寫者都提到電子Von Frey觸痛儀的測試絲的直徑不均是個嚴(yán)重的問題。有技術(shù)的 “Supertips™” 15根不同的檢測絲直徑都在0.8mm ,具有極度的均一性。這種技術(shù)只有本公司公司的電子測痛儀才有這種特性。探針尺寸不再是影響痛閾或者壓力閾的因素,實驗結(jié)果終于可以比對!均可單獨(dú)預(yù)訂。
電子Von Frey觸痛儀由于槍頭末端的吸濕性能消除無效數(shù)據(jù)收集(實驗證明:在相對濕度28-52%的變化可能導(dǎo)致壓力高達(dá)的變化!)只有讀數(shù)器準(zhǔn)確才能讀出準(zhǔn)確的數(shù)值。任何情況下不同程度的彎曲能改變20-30%的數(shù)值,這個通過讀數(shù)器可以看出來。柔韌的槍頭末端的天然抗折力有很大的優(yōu)勢。不需要上下來回的找起點。如果不使用外接電源,電池壽命為50小時 (理論上)
參考文獻(xiàn):
1. Effects on Birth Weight and Adult Health in Rats Prenatally Exposed to Toxicants or Undernutrition.
Brain E. Grey, Brenda Barbee, Kaberi Das, Joel Norwood, Christopher Lau, and John M. Rogers.
Reproductive Toxicology Division, NHEERL, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC
Poster Presented at SOT 2007
2. Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist
Ranjinidevi Ambalavanar, Masayuki Moritani, Aicha Moutanni, Panduranga Gangula, Chandrasekha Yallampalli, Dean Dessem
Pain 120 (2007) 53-68
3. Evaluation of a von Frey Device for Pharmacoddynamic Modeling of Morphine in Dogs.
Butch KuKanich, B. Duncan X. Lascelles, Mark G. Papich
Comparatrive Pain and Pharmacology Research Laboratories
4. An electronic pressure-meter nociception paw test for rats
G.G. Vivancos, W.A. Verri Jr, T.M. Cunha, I.R.S. Schivo, C.A. Parada,
F.Q. Cunha and S.H. Ferreira
Brazilian Journal of Medical and Biological Research (2004) 37:391-399
5. An electronic pressure-meter nociception paw test for rats
G.G. Vivancos, W.A. Verri Jr, T.M. Cunha, I.R.S. Schivo, C.A. Parada,
F.Q. Cunha and S.H. Ferreira
Brazilian Journal of Medical and Biological Research (2004) 37:401-407
6. Assessment of von Frey device for evalution of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs
Butch KuKanich, DVM, PhD; B. Duncan X. Lascelles, BVSc, PhD; Mark G. Papich, DVM, MS
American journal of Veterinary Research 2005 66(9).
7. Cairns BE, Gambarota G, Svensson P, Arendt-Nielsen L, Berde CB. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience, 2002; 109: 389-399.
8. Arpad Dobolyi, Hiroshi Ueda, Hitoshi Uchida, Miklos Palkovits, and Ted B. Usdin, Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. , , PNAS, February 5, 2002, volume. 99, no. 3, 1651 to 1656
9. Jensen K. Andersen et al: Pressure-Pain threshold In Human Temporal Region. Evaluation of A New Pressure Algometer Pain, 1986;25:313-23. (This is why"SupertipsTM" exist!) Poster at IASP Congress San Diego 2002
10. 437-P71 Performance of Von frey polyamide Monofilaments During Changes in relative Humidity: A Calibration Study. Per R. Neilsen, Mads U. Werner, Catarina Ellehuus. Dept Anesthesiology, Univ Hospital, Hvidovre, Denmark (spon: Per R. Nielsen)
11. Assessment of Stimulation Parameters Used In Measuring Mechanical Hyperalgesia In Animal Models Of Pain. Harry J. Gould, III, R. Denis Soignier, Porter Nolan, Sarah J. Vitale, and Dennis Paul. Departments of Neurology and Pharmacology, and Neuroscience Center of Excellence LSU Health Sciences Center, New Orleans, LA, USA 70112
12. Abstract: Validation of an Electronic Von Frey Device in a Rat Model of Incisional Pain and its use in Assessing the Efficacy of Clinically Relevant Analgescis. L. Mark; G. Whiteside, J. Boulet, K. Walker., Discovery Research, Purdue Pharma, Cranbury, NJ, USA (presented at SFN 2003)